Hirobumi Tokuyama Selected Research

Sirtuin 1

1/2022	The significance of NAD + metabolites and nicotinamide N-methyltransferase in chronic kidney disease.
1/2016	Communication from Tubular Epithelial Cells to Podocytes through Sirt1 and Nicotinic Acid Metabolism.
11/2013	Renal tubular Sirt1 attenuates diabetic albuminuria by epigenetically suppressing Claudin-1 overexpression in podocytes.
4/2010	Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function.

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Hirobumi Tokuyama Research Topics

Disease

6	Diabetic Nephropathies (Diabetic Nephropathy) 01/2021 - 01/2010
6	Proteinuria 01/2021 - 01/2008
5	Inflammation (Inflammations) 01/2022 - 01/2007
4	Hypertrophy 10/2022 - 01/2011
4	Fibrosis (Cirrhosis) 01/2022 - 09/2011
4	Chronic Renal Insufficiency 01/2022 - 04/2015
4	Interstitial Nephritis (Tubulointerstitial Nephritis) 01/2019 - 10/2010
4	Albuminuria 01/2019 - 11/2013
4	Insulin Resistance 03/2016 - 12/2002
4	Ischemia 01/2007 - 05/2002
3	Obesity 10/2022 - 09/2008
3	Autosomal Dominant Polycystic Kidney (ADPKD) 01/2020 - 11/2012
3	Glomerulonephritis 06/2012 - 01/2008
2	Chronic Kidney Failure (Chronic Renal Failure) 01/2021 - 02/2005
2	Neoplasms (Cancer) 01/2021 - 01/2019
2	Aneurysm (Aneurysms) 01/2020 - 11/2012
2	Kidney Diseases (Kidney Disease) 01/2020 - 10/2015
2	IGA Glomerulonephritis (IGA Nephropathy) 01/2020 - 01/2008
2	Acute Kidney Injury (Acute Renal Failure) 01/2019 - 04/2010
2	Fever (Fevers) 01/2019 - 01/2018
2	Hypoxia (Hypoxemia) 01/2019 - 11/2016
2	Infections 01/2019 - 03/2018
2	Renal Insufficiency (Renal Failure) 11/2018 - 03/2016
2	Amyloidosis 01/2018 - 10/2011
2	Renal Artery Obstruction (Renal Artery Stenosis) 07/2002 - 05/2002
1	Fabry Disease (Fabry's Disease) 01/2022
1	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 01/2021
1	Membranous Glomerulonephritis (Membranous Nephropathy) 01/2021
1	Hypoalbuminemia 01/2021
1	Nephrotic Syndrome (Syndrome, Nephrotic) 01/2021
1	Congenital Heart Defects (Congenital Heart Defect) 01/2021
1	Segmental glomerulosclerosis 01/2021
1	Cerebral Infarction 01/2020
1	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2020
1	Rupture 01/2020
1	Intracranial Hemorrhages (Intracranial Hemorrhage) 01/2020
1	Lung Neoplasms (Lung Cancer) 01/2019
1	Renal Cell Carcinoma (Grawitz Tumor) 01/2019
1	Cysts 01/2019
1	Chills 01/2019
1	Prostatitis 01/2019
1	Flank Pain 01/2019
1	Calciphylaxis 11/2018
1	Peritonitis 03/2018
1	Arthritis (Polyarthritis) 01/2018

Drug/Important Bio-Agent (IBA)

4	Sirtuin 1IBA 01/2022 - 04/2010
4	EnzymesIBA 01/2019 - 02/2005
3	Angiotensin IIIBA 10/2015 - 05/2002
3	AngiotensinsIBA 10/2015 - 07/2002
3	rho-Associated KinasesIBA 09/2011 - 09/2008
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 02/2005 - 05/2002
2	Proteins (Proteins, Gene)FDA Link 10/2022 - 01/2019
2	NAD (NADH)IBA 01/2022 - 01/2018
2	Methionine (L-Methionine)FDA Link 01/2022 - 01/2018
2	N-nitroso-N-methyltyramine (NNMT)IBA 01/2022 - 01/2018
2	AntibodiesIBA 01/2021 - 11/2015
2	Nicotinamide MononucleotideIBA 01/2021 - 01/2019
2	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 01/2011
2	AldosteroneIBA 10/2020 - 04/2015
2	Streptozocin (Streptozotocin)FDA Link 01/2019 - 11/2013
2	Bicarbonates (Hydrogen Carbonate)IBA 11/2018 - 11/2015
2	C-Reactive ProteinIBA 01/2018 - 03/2016
2	LipidsIBA 03/2016 - 01/2011
2	N,N-dimethylarginine (asymmetric dimethylarginine)IBA 03/2016 - 04/2015
2	ReninIBA 10/2015 - 01/2010
2	fasudil (AT 877)IBA 09/2011 - 01/2011
2	ChemokinesIBA 09/2008 - 01/2007
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2008 - 01/2007
2	ProstaglandinsIBA 09/2002 - 05/2002
1	Protein Kinases (Protein Kinase)IBA 10/2022
1	Cyclin-Dependent Kinases (cdk Proteins)IBA 10/2022
1	Connective Tissue Growth FactorIBA 01/2022
1	alpha-Galactosidase (Beano)IBA 01/2022
1	Nicotinamide N-MethyltransferaseIBA 01/2022
1	Sunitinib (Sutent)FDA Link 01/2021
1	AntigensIBA 01/2021
1	SteroidsIBA 01/2021
1	Phospholipase A2 ReceptorsIBA 01/2021
1	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2020
1	CytosineIBA 01/2020
1	DNA (Deoxyribonucleic Acid)IBA 01/2020
1	Histone Deacetylases (Histone Deacetylase)IBA 01/2019
1	Histones (Histone)IBA 01/2019
1	NivolumabIBA 01/2019
1	Levofloxacin (Levaquin)FDA Link 01/2019
1	Nicotinamide PhosphoribosyltransferaseIBA 01/2019
1	sodium thiosulfate FDA Link 11/2018
1	Warfarin (Coumadin)FDA LinkGeneric 11/2018
1	Lactic Acid (Lactate)FDA LinkGeneric 11/2018
1	Anti-Bacterial Agents (Antibiotics)IBA 03/2018
1	VLDL LipoproteinsIBA 01/2018
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2018

Therapy/Procedure

7	Therapeutics 01/2021 - 01/2010
4	Peritoneal Dialysis 01/2019 - 09/2011
3	Renal Dialysis (Hemodialysis) 01/2020 - 01/2018
1	Resistance Training 12/2021
1	Operative Surgical Procedures 01/2021
1	Renal Replacement Therapy (Therapies, Renal Replacement) 01/2021
1	Fontan Procedure (Fontan Operation) 01/2021
1	Catheters 03/2018